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Although 1 out of 3 people who uses androgenic-anabolic steroids develops a steroid use disorder, the effects of the drugs on the central nervous system and the psyche are still not well understood. This review seeks to provide an early overview of the relationship between use of androgenic anabolic steroids and their related clinical and laboratory effects on the central nervous system and the psychological states. Androgenic-anabolic steroids (AASs) are long-term synthetic steroidal compounds that have their use restricted to sports. AASs come in forms for intramuscular, intrapulmonary, and topical use. Intramuscular AASs are the most commonly used AASs because they can be taken continuously during competition. Intrapulmonary AASs are used for exercise and for prevention of fatigue during training. They are not used during competition. Intranasal AASs are for administration into the nasal mucosa. The various oral AASs (e.g. propionate) have not been widely studied for cardiovascular and respiratory effects. However, the AASs act on the androgen receptor and are classified as androgens. These androgens exert their effects by binding to the androgen receptor that is expressed particularly in the central nervous system. As stated earlier it has been established that both intranasal and intramuscular AASs stimulate the androgen receptor and cause an increase in serum testosterone levels. These AASs also increase heart rate and respiration as well as increase blood pressure and cardiac contractility (Werner, 1993; St. Amand et al. 1990; Wilson and Glynn, 1994). Many of these effects would be seen as side effects of AAS use as well, such as increased sweating and the production of body odor as a consequence of increased metabolism and vasoconstriction (Johnson et al., 1985; Wiebking et al., 1984). Moreover, the AAS affect other peripheral organs as well, such as kidney, heart, and vascular function. Indeed, the central nervous system effects of AAS use have been extensively studied by researchers. Many of the effects seen in animal studies have been found in humans as well, when AASs were used for the prevention of or as an aid in treatment of the following conditions: (1) obesity, (2) cardiovascular disease, (3) osteoporosis, (4) obesity associated with insulin resistance or hyperinsulinemia, and (5) aging. All these different effects of AAS use in AAS are related to the presence of or levels of androgens to which these androgens are bound. The present review concentrates on studies Similar articles:

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